Charles D Smith Selected Research

olsalazine (Dipentum)

4/2010	Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.
4/2008	Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase.

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Charles D Smith Research Topics

Disease

49	Neoplasms (Cancer) 01/2018 - 01/2003
10	Inflammation (Inflammations) 01/2018 - 11/2006
8	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 06/2006
7	Dementia (Dementias) 10/2014 - 11/2004
6	Cognitive Dysfunction 01/2017 - 07/2009
5	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 06/2006
5	Muscular Diseases (Myopathy) 01/2021 - 06/2006
5	Prostatic Neoplasms (Prostate Cancer) 12/2015 - 07/2008
5	Parkinson Disease (Parkinson's Disease) 01/2015 - 02/2005
4	Osteitis Deformans (Paget's Disease of Bone) 01/2021 - 06/2006
4	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 01/2021 - 06/2006
4	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 07/2015 - 06/2006
4	Adenocarcinoma 12/2011 - 04/2010
3	Carcinogenesis 01/2017 - 03/2005
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 06/2006
3	Lymphoma (Lymphomas) 09/2015 - 01/2009
3	Hypoxia (Hypoxemia) 11/2013 - 01/2012
3	Arthritis (Polyarthritis) 10/2013 - 03/2009
3	Carcinoma (Carcinomatosis) 12/2011 - 05/2010
3	Breast Neoplasms (Breast Cancer) 04/2011 - 06/2008
3	Hematologic Neoplasms (Hematological Malignancy) 01/2011 - 06/2009
3	Disease Progression 04/2010 - 07/2005
3	Melanoma (Melanoma, Malignant) 06/2008 - 03/2005
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 07/2011
2	Epilepsy (Aura) 07/2015 - 10/2005
2	Hippocampal Sclerosis 07/2015 - 05/2011
2	Ischemia 11/2013 - 01/2012
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2013 - 04/2008
2	Giardiasis 08/2011 - 08/2011
2	Hepatocellular Carcinoma (Hepatoma) 08/2011 - 03/2011
2	Colonic Neoplasms (Colon Cancer) 08/2011 - 10/2010
2	Weight Loss (Weight Reduction) 11/2010 - 01/2003
2	Leukemia 06/2009 - 01/2009
1	Proteostasis Deficiencies 01/2021
1	Atrophy 01/2018
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2018
1	Lung Neoplasms (Lung Cancer) 01/2018
1	Kaposi Sarcoma (Kaposi's Sarcoma) 12/2017
1	Glioblastoma (Glioblastoma Multiforme) 10/2017
1	Optic Nerve Diseases (Optic Neuropathy) 10/2017
1	Vomiting 08/2017

Drug/Important Bio-Agent (IBA)

21	3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA 01/2018 - 04/2010
17	sphingosine kinaseIBA 01/2018 - 09/2003
16	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2004
15	SphingosineIBA 01/2018 - 01/2011
12	Sorafenib (BAY 43-9006)FDA Link 04/2016 - 08/2006
11	Phosphotransferases (Kinase)IBA 01/2018 - 03/2005
11	Pharmaceutical PreparationsIBA 08/2017 - 01/2003
9	SphingolipidsIBA 01/2018 - 11/2010
9	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2018 - 11/2011
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 11/2006
7	CeramidesIBA 12/2017 - 06/2008
7	Biomarkers (Surrogate Marker)IBA 01/2017 - 06/2006
7	EnzymesIBA 12/2015 - 09/2003
4	Protein Kinases (Protein Kinase)IBA 01/2018 - 01/2009
4	Small Interfering RNA (siRNA)IBA 10/2013 - 03/2005
4	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 07/2011 - 01/2003
4	ApolipoproteinsIBA 05/2011 - 03/2006
3	UbiquitinIBA 01/2021 - 06/2006
3	Indicators and Reagents (Reagents)IBA 01/2017 - 07/2011
3	Hormones (Hormone)IBA 01/2015 - 04/2011
3	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2011 - 01/2003
3	Mitogen-Activated Protein KinasesIBA 06/2008 - 03/2005
3	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 04/2007 - 02/2005
3	Valosin Containing ProteinIBA 02/2007 - 06/2006
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2018 - 06/2015
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 05/2013
2	CytokinesIBA 01/2018 - 01/2012
2	IsoenzymesIBA 01/2018 - 11/2011
2	Gemcitabine FDA Link 09/2016 - 08/2011
2	Eosine Yellowish-(YS) (Eosin)IBA 07/2015 - 05/2011
2	Phosphates (Orthophosphate)IBA 01/2015 - 11/2011
2	Messenger RNA (mRNA)IBA 01/2012 - 07/2006
2	Fluorouracil (Carac)FDA LinkGeneric 08/2011 - 08/2011
2	Quinacrine (Mepacrine)IBA 08/2011 - 08/2011
2	Antimitotic AgentsIBA 07/2011 - 07/2007
2	DNA (Deoxyribonucleic Acid)IBA 07/2011 - 05/2011
2	proto-oncogene proteins pimIBA 01/2011 - 01/2010
2	Serine (L-Serine)FDA Link 01/2011 - 01/2010
2	Threonine (L-Threonine)FDA Link 01/2011 - 01/2010
2	Dextran SulfateIBA 10/2010 - 04/2008
2	Apolipoprotein E4IBA 10/2010 - 07/2010
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 05/2010 - 01/2007
2	olsalazine (Dipentum)FDA Link 04/2010 - 04/2008
2	DNA-Binding Proteins (DNA Binding Protein)IBA 07/2009 - 02/2007
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2008 - 08/2006
2	Apolipoproteins E (ApoE)IBA 01/2007 - 03/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2006 - 03/2005
2	N- 1- benzyl- 2,3- dihydro- 1H- pyrrolo(2,3- b)quinolin- 4- yl- 2- phenylacetamideIBA 03/2004 - 01/2003
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021
1	Merozoite Surface Protein 1 (MSA1)IBA 01/2021
1	17-hydroxyestrane-3-carbonitrile (ECN)IBA 01/2019
1	Caspase 3 (Caspase-3)IBA 01/2018
1	Pemetrexed (MTA)FDA Link 01/2018
1	Glycogen Synthase (Synthase I)IBA 01/2018
1	Temozolomide (Temodar)FDA LinkGeneric 10/2017
1	LipidsIBA 08/2017

Therapy/Procedure

12	Therapeutics 12/2015 - 07/2005
8	Drug Therapy (Chemotherapy) 10/2017 - 01/2003
4	Oral Administration 01/2018 - 04/2010